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What are GLP-1s?

Written by Maria Maureen Ablen

Published 12/06/2024

Updated 05/01/2025

GLP-1s have emerged as one of the most promising breakthroughs in the fields of diabetes care and weight loss. For many people in the Philippines, where metabolic conditions like type 2 diabetes and obesity are on the rise, these medications are becoming a central part of modern treatment plans. But what exactly are GLP-1s? How do they work? And more importantly—are they safe and accessible for Filipinos?

This comprehensive guide explains everything you need to know about GLP-1 receptor agonists, how they’re used, and why they might be the missing link in your long-term health journey.

What Does GLP-1 Stand For?

GLP-1 stands for glucagon-like peptide-1, a naturally occurring hormone that plays a critical role in regulating blood sugar and hunger. It’s secreted by the intestines when you eat and triggers a cascade of physiological responses:

It prompts the pancreas to release insulin, helping lower blood sugar.
It slows gastric emptying, making you feel full longer.
It signals satiety to the brain, reducing cravings and portion sizes.
It decreases the secretion of glucagon, a hormone that raises blood sugar.

For people with metabolic dysfunctions, such as insulin resistance or obesity, natural GLP-1 levels are often insufficient or ineffective. That’s where GLP-1 receptor agonists come in.

How GLP-1 Receptor Agonists Work

GLP-1 receptor agonists are medications that mimic the effects of the natural GLP-1 hormone. They bind to GLP-1 receptors in your body and amplify the hormone’s impact, helping restore balance in glucose regulation and appetite control.

These medications come in various forms, including weekly injections like Ozempic (semaglutide) and daily injections such as Saxenda (liraglutide). Newer oral formulations are also in development, offering more flexibility for patients.

What makes GLP-1s distinct from older weight loss pills or diabetes treatments is their multi-functional approach: they simultaneously address glucose levels, hunger, and fat storage. This triple-action mechanism makes them ideal for patients who have tried calorie restriction or exercise alone without lasting results.

In the Philippines, this multifaceted effect is especially valuable given the cultural challenges around diet and physical activity. Many Filipinos face barriers such as high-carb traditional meals, sedentary urban lifestyles, and limited access to long-term nutrition guidance.

GLP-1 Medications Commonly Used in the Philippines

While GLP-1 therapies originated for diabetes treatment, they have rapidly gained traction as anti-obesity medications. Here are some of the most commonly used GLP-1 drugs available by prescription:

Ozempic® (Semaglutide) – Originally designed for diabetes, it's now widely used off-label for weight loss due to its strong appetite-suppressing effects.
Saxenda® (Liraglutide) – FDA-approved specifically for chronic weight management.
Wegovy® (Semaglutide) – Similar to Ozempic but with a higher dose intended exclusively for weight loss.

According to the American Diabetes Association, GLP-1s are now part of first-line therapy options for people with type 2 diabetes who are overweight or have cardiovascular risk factors.

In the Philippines, brands like Ozempic and Saxenda can be accessed through licensed platforms like andyou.ph, where local doctors assess your condition via telehealth before issuing prescriptions.

Benefits Beyond Weight Loss

The impact of GLP-1s goes far beyond shedding pounds. These medications offer protective benefits that can significantly improve quality of life, especially for Filipinos at risk of lifestyle-related diseases.

Key Benefits:

Improved insulin sensitivity, lowering the risk of type 2 diabetes
Reduced risk of cardiovascular disease, a major cause of death in the Philippines
Better emotional control around food and stress eating
Longer satiety leading to fewer binge cycles or evening cravings

Research published in JAMA has shown that GLP-1s like semaglutide help patients lose weight and maintain weight loss better than lifestyle changes alone.

Real-World Use Cases for Filipinos

Let’s take a closer look at how GLP-1s are being used in everyday Filipino lives:

Gina, 42, from Cebu, had tried intermittent fasting and various diet trends. But it wasn’t until her doctor introduced a GLP-1 medication that she finally started seeing meaningful and lasting results. Her story echoes that of many others, particularly those dealing with stress-related eating or sugar cravings.

In Quezon City, Marco—a 36-year-old call center agent—shared that he was able to get his blood sugar levels under control and lost over 9 kilos after three months on a GLP-1 prescription. These personal experiences reflect a broader shift in how metabolic health is managed in the country. Other Filipinos have explored different weight loss tools, including newer injectables discussed in posts like prescription treatments for weight loss in the Philippines.

Safety and Side Effects

GLP-1 medications are generally well tolerated, but they aren’t without risks.

Most common side effects include:

Nausea
Mild headaches
Bloating or gas
Fatigue

These usually lessen after a few weeks as the body adapts. However, anyone experiencing severe side effects should consult a doctor immediately.

Serious (but rare) risks:

Pancreatitis
Kidney issues
Gallstones
Possible increased risk of thyroid tumors (based on rodent data)

It’s important to undergo a proper evaluation before starting treatment. At andyou.ph, your consultation includes screening for medical conditions that could make GLP-1 use risky.

Starting GLP-1 Treatment in the Philippines

Thanks to platforms like andyou.ph, accessing GLP-1 therapy in the Philippines is no longer limited to specialists in Metro Manila.

The Process:

Take the online health quiz
Consult with a licensed Filipino doctor
Receive a prescription if medically appropriate
Cold-packed medication is delivered to your home discreetly

This model not only improves convenience but also helps break down stigma around weight loss and diabetes care.

What to Expect After Starting

Patients typically begin with a starter dose to minimize gastrointestinal discomfort. After a few weeks, the dose may be increased based on tolerance and treatment goals.

Weight loss results can often be seen within 8–12 weeks, but consistent lifestyle changes enhance these results. Success tends to be highest among people who combine GLP-1 therapy with a structured approach to meal planning and physical activity. This is especially true for individuals facing hormonal imbalances.

One study published in Nature Reviews Endocrinology reported that patients using GLP-1s experienced weight reduction and improved cardiovascular markers even without intensive diet counseling.

How They Compare to Traditional Options

Traditional weight loss supplements popular in the Philippines—such as fat-burning teas or detox juices—lack the scientific backing GLP-1s have. Appetite suppressants, another common option, often lead to rebound eating or mood swings.

GLP-1s, on the other hand:

Are backed by clinical trials
Offer metabolic and hormonal support
Are tailored to individual medical profiles

Compared to medications like Orlistat, which block fat absorption but don’t affect hunger, GLP-1s work deeper within the body’s metabolic system. While some Filipinos continue to explore options like natural remedies for weight loss, those seeking clinical results often turn to GLP-1s for consistent progress.

Should You Try GLP-1s?

GLP-1s are more than just a trend. They’re a medically sound, long-term option for Filipinos who are ready to take control of their health with the guidance of a doctor. These medications are effective, accessible, and scientifically backed.

If you’re tired of quick fixes and want something that addresses the root of your weight or metabolic issue, GLP-1s may be the step forward you’ve been waiting for.

Visit andyou.ph to find out if GLP-1 therapy is right for you—and start your journey with personalized, doctor-guided care today.

Maria Maureen Ablen

Dr. Maria Maureen Ablen is a board-certified medical professional with a strong background in clinical care, healthcare innovation, and academic research. She is dedicated to advancing health and wellness through evidence-based practice and compassionate care.