Here's what we'll cover

Home / Weight Loss

Tirzepatide for Weight Loss: How It Works and Why It's Different from Ozempic

Published 04/25/2025

Updated 04/25/2025

Tirzepatide is quickly gaining attention as a new breakthrough treatment for weight loss, especially among those in the Philippines looking for medical support beyond traditional diet and exercise. While Ozempic (semaglutide) has dominated headlines in the past year, tirzepatide introduces a new dual-action mechanism that could change the game for many Filipinos. But what exactly is tirzepatide, how does it work, and how does it compare to Ozempic?

What Is Tirzepatide?

Tirzepatide is a once-weekly injectable medication originally developed to manage type 2 diabetes. It belongs to a class of drugs called GLP-1 receptor agonists—but with a twist. Tirzepatide also targets a second hormone pathway, GIP (glucose-dependent insulinotropic polypeptide), making it the first dual GIP/GLP-1 receptor agonist available.

This unique dual-target approach is what sets tirzepatide apart from existing weight loss medications like semaglutide, which only act on the GLP-1 receptor. Tirzepatide is marketed under the brand name Mounjaro and has shown significant results in both glycemic control and weight reduction in clinical trials.

How Tirzepatide Works for Weight Loss

Tirzepatide works by mimicking two hormones—GLP-1 and GIP—that regulate appetite, glucose metabolism, and insulin sensitivity. When combined, these hormones have a powerful effect on how your body handles food and stores fat.

Reduces Appetite: Signals the brain that you’re full, reducing food intake
Slows Gastric Emptying: Keeps you feeling full longer
Improves Insulin Sensitivity: Helps your body regulate blood sugar more efficiently
Targets Fat Storage: May have a more direct impact on how your body stores fat compared to other GLP-1 drugs

This multi-hormonal approach leads to both immediate appetite suppression and long-term metabolic changes, making it ideal for sustainable weight loss. According to Cleveland Clinic, the dual action helps improve energy use and reduce fat accumulation more effectively.

Beyond these benefits, some research has shown that patients on tirzepatide also experience improvements in cardiovascular risk markers. These include lower triglycerides and LDL cholesterol, both of which are common concerns among Filipinos due to high intake of fried foods and processed snacks.

What Makes Tirzepatide Different from Ozempic?

Both tirzepatide and Ozempic are injectable medications, taken once a week. Both help with weight loss by mimicking hormones involved in appetite and metabolism. But there are several key differences:

Dual Agonist vs. Single Agonist: Tirzepatide acts on both GIP and GLP-1 receptors, while Ozempic only targets GLP-1.
Greater Weight Loss Potential: Clinical studies like SURMOUNT-1 show tirzepatide may lead to greater average weight loss compared to semaglutide.
Broader Metabolic Impact: Because of its GIP activity, tirzepatide may offer improved fat metabolism and insulin sensitivity.

If you're interested in learning more about Ozempic, we’ve covered its role in weight management here.

Clinical Study Highlights

According to results from the SURMOUNT-1 trial, patients using tirzepatide lost an average of 15% to 21% of their body weight over 72 weeks. This is significantly more than what’s been observed in most Ozempic trials.

A key study published in the New England Journal of Medicine also reported that tirzepatide led to substantial improvements in cholesterol levels, blood pressure, and markers of metabolic syndrome.

Other studies referenced by the American Diabetes Association suggest the dual hormone approach helps address insulin resistance more effectively than GLP-1 alone.

How Does It Compare in the Real World?

In everyday clinical settings, physicians report that patients on tirzepatide tend to see faster results with less need for strict dietary control. That said, medication is only as effective as the lifestyle supporting it. Nutrition, movement, and sleep still play a vital role in long-term success.

Patients often report reduced snacking, fewer cravings for sweets or carbs, and improved focus and energy levels throughout the day—benefits that extend beyond just numbers on a scale.

Common Side Effects and Considerations

As with any medication, tirzepatide may cause side effects. Most are mild and temporary:

Nausea
Diarrhea
Constipation
Injection site irritation

These often diminish as your body adjusts. However, tirzepatide is not recommended for individuals with a history of certain thyroid tumors or pancreatitis. The FDA advises careful screening before use.

It's important to follow dosage instructions carefully and report any unusual symptoms to your healthcare provider. Having routine follow-ups is essential to ensure the treatment remains both safe and effective.

Who Is Tirzepatide Right For?

Tirzepatide may be a good fit if you:

Have a BMI over 27 and are experiencing weight-related health issues
Have tried diet and exercise without sustained success
Are looking for a medically guided, sustainable weight loss approach

Tirzepatide is also being considered for individuals with polycystic ovary syndrome (PCOS), a common condition among women in the Philippines. While more research is needed, the potential hormonal benefits of tirzepatide could make it useful for addressing weight gain and insulin resistance associated with PCOS.

andyou.ph offers consultations with licensed Filipino doctors to help determine if tirzepatide is appropriate for your goals and health profile.

How Tirzepatide Fits into a Filipino Lifestyle

While medication helps, lifestyle still matters. Filipino food culture is rich and flavorful—but often heavy in rice, fried foods, and sweets. Tirzepatide’s ability to reduce appetite and improve insulin sensitivity makes it easier to adopt more balanced meals. Pairing it with increased physical activity and mindful eating leads to sustainable outcomes.

Meal planning is key. Switching from white to brown rice, reducing sugary drinks like soda or milk tea, and prioritizing protein at each meal can drastically improve results.

Making use of local vegetables like malunggay, kangkong, and squash can enhance your nutrition without breaking the bank. Meal prepping and shopping with a list can prevent impulse buying and support consistency.

Accessing Tirzepatide in the Philippines

Tirzepatide is now available through our medically guided weight loss programs at andyou, providing Filipinos direct access to one of the most advanced treatments on the market. Whether you’re just exploring your options or ready to begin your treatment, our licensed Filipino doctors can help personalize your care.

If you're curious about which weight loss treatments are most accessible today, check out our guide to prescription options in the Philippines.

You may also want to consult your HMO or private healthcare provider about coverage and options for accessing tirzepatide locally. As availability expands, andyou.ph will continue updating its weight loss services to include this promising option.

Final Thoughts

Tirzepatide is one of the most promising new treatments for weight loss, especially for those who haven’t had success with traditional approaches. Its dual-action mechanism offers a broader metabolic benefit and could reshape how we think about long-term weight management.

Whether you're just starting your weight loss journey or have tried other methods with limited success, tirzepatide could be the next step forward. With support from healthcare professionals at andyou.ph, you can explore a solution that aligns with your body, lifestyle, and goals.

To learn more or see if you're eligible for medically guided weight loss, visit andyou.ph and speak with a licensed physician today.