Semaglutide vs. Tirzepatide: Which Weight Loss Shot Is Better?

Written by Sexual Health Team

Published 09/22/2025

Updated 09/30/2025

Here's what we'll cover

Semaglutide and tirzepatide have emerged as leading injectable medications for weight loss, gaining attention in both clinical settings and online spaces. In the Philippines, where weight management is a growing concern due to rising obesity rates and related conditions like diabetes and hypertension, the interest in these drugs is particularly strong. But between the two, which one truly delivers better results for Filipinos looking to manage their weight safely and effectively?

These medications are not magic solutions. They're tools meant to support long-term lifestyle changes. Knowing the differences can help Filipinos make smarter health decisions. Before diving in, you can explore our health guides about nutrition and lifestyle changes that support long-term weight management. For additional insights on injectable treatments and weight loss trends, check out our article on GLP-1 medications.

How These Weight Loss Injections Actually Work

Semaglutide, sold under brand names like Ozempic and Wegovy, is a GLP-1 receptor agonist. It mimics the body's natural hormones to help regulate blood sugar, suppress appetite, and promote feelings of fullness. Tirzepatide, branded as Mounjaro, is a newer medication. It combines GLP-1 with another hormone called GIP (glucose-dependent insulinotropic polypeptide), creating a dual-action effect that amplifies weight loss benefits. Semaglutide is approved for type 2 diabetes. Some doctors may prescribe it for weight management, but any such use must be under medical supervision and subject to local regulations. Tirzepatide, while newer, has shown promising results in head-to-head trials. In the Philippine context, both drugs are gaining traction through private clinics and online forums, though access remains limited and often expensive. These medications are prescription-only and may be available only through licensed medical providers. For a clear breakdown of semaglutide’s benefits, Healthline offers a detailed explanation.

Filipinos should also understand how these injections fit into the broader picture of metabolic health. GLP-1 and GIP hormones not only aid in appetite regulation but also influence insulin sensitivity, which is crucial in a country where type 2 diabetes rates are on the rise. This mechanism supports both weight loss and blood sugar control, particularly relevant to the Filipino population’s risk profile.

Which Medication Works Better Based on Clinical Evidence

In clinical studies, tirzepatide has often shown superior weight loss results. The SURMOUNT-1 trial revealed that people taking tirzepatide lost an average of 15 to 21 percent of their body weight over 72 weeks. By comparison, the STEP 1 trial on semaglutide recorded an average weight loss of around 15 percent.

These numbers are impressive, but real-world results vary based on multiple factors:

Adherence to a balanced diet and regular physical activity
Individual metabolism and medical history
Duration of treatment and consistency

Science Direct also highlights the efficacy of tirzepatide in managing weight alongside glycemic control. Filipinos considering either drug should weigh not only the trial results but also the practical realities of cost, access, and lifestyle compatibility. A BioMed Central analysis supports the dual-action impact of tirzepatide, showing its edge over single-hormone treatments. One important consideration is that while tirzepatide may offer greater weight loss, semaglutide’s longer track record gives doctors more data to reference, especially in long-term use. This matters when making medical decisions that involve extended treatment timelines.

Possible Side Effects to Watch Out For

Both medications come with similar side effects, although their intensity and duration can differ from person to person.

Common side effects include:

Nausea and vomiting
Diarrhea or constipation
Fatigue
Headaches

Less common but serious risks:

Pancreatitis
Gallbladder issues
Kidney function problems
Possible thyroid tumors (observed in animal studies)

The European Medicines Agency emphasizes that these medications are safe when used under medical supervision. However, they are not recommended for people with a history of certain cancers or pancreatitis. Locally, Filipino patients should always consult a licensed doctor. Consult a licensed Filipino doctor for personalized medical advice about treatment options. Anecdotal accounts from Filipinos who have tried these injections often mention side effects easing after the first few weeks. Still, individual reactions vary widely. Some patients report better tolerance with semaglutide, while others adjust more easily to tirzepatide.

Costs and Access in the Philippines

Affordability is a major barrier and both drugs require refrigeration, complicating use in areas with unreliable power or limited access to cold storage. Due to these hurdles, Some Filipinos explore non-prescription approaches such as lifestyle modification and over-the-counter supplements, but these should still be used responsibly. These include clinically backed supplements that support fat metabolism, appetite control, and energy levels. A virtual consultation with a licensed Filipino doctor can help assess whether injectables, alternatives, or a combination approach is most suitable. Additional costs to consider include lab work, transportation to clinics, and routine follow-ups. When choosing a treatment, it’s helpful to calculate the total cost of care, not just the medication itself.

How Culture and Lifestyle Shape Results

For many Filipinos, lifestyle and cultural habits play a big role in weight management. Choice of medication depends on a doctor’s assessment, access, and affordability. Availability may differ by clinic or pharmacy.

Additionally, the Filipino diet rich in white rice, processed snacks, and sugary drinks demands more than just appetite suppression. Real change requires:

Education on balanced local meal planning
Community fitness programs such as barangay Zumba or walking groups
Affordable, science-backed supplements

Our guide on losing weight without giving up rice dives deeper into habits and diet that affect weight loss. You might also be interested in the GLP-1 diet plan for a comprehensive look at local food adjustments. Science Direct also explains how culture-specific behaviors influence diet and weight outcomes. One often-overlooked factor is emotional eating. In Filipino households, food is central to social gatherings and comfort. Strategies such as mindful eating, journaling, and support from friends or health coaches can make a big difference.

Finding a Personalized Weight Loss Strategy That Works

Injectables may not be suitable for every Filipino, whether due to cost, accessibility, or personal comfort. Fortunately, there are effective alternatives that don’t require a prescription or refrigeration.

These options include:

Natural fat metabolism boosters and appetite control supplements that are clinically studied and safe
Telehealth consultations with licensed Filipino doctors for expert guidance on non-injectable weight loss strategies
Incorporating sustainable lifestyle changes such as walking more, cooking at home, and monitoring portions

You can also explore complementary lifestyle practices like mindful eating, food journaling, and joining community support groups, which make staying on track easier. For more support on your journey, browse our collection of lifestyle and health guides in the Andyou Health Club that include science-based advice for realistic diet plans and changes that you can incorporate in your daily life. These resources help Filipinos create a plan that works in the long term, with or without injections.

This article is for educational purposes only and does not replace medical advice from a licensed professional. Prescription medications such as semaglutide and tirzepatide should only be used under doctor supervision. Compounded versions are not FDA-approved in the Philippines.

Sexual Health Team

The &you Sexual Health Team provides private, science-backed care for issues like ED and low libido. With licensed doctors and pharmacists guiding every step, we offer trusted treatments, holistic support, and a judgment-free path toward confidence and sexual well-being.