How Long Can You Take Semaglutide for Weight Loss?

Written by Weight Loss Team

Published 06/18/2025

Updated 07/11/2025

Here's what we'll cover

Semaglutide has quickly become one of the most talked-about weight loss medications—not just globally, but also here in the Philippines. From celebrities to everyday Filipinos sharing their transformation stories online, it’s hard to ignore the buzz around this once-weekly injectable that promises significant weight loss without traditional crash diets.

But alongside the hype comes an important question: How long can you safely take semaglutide for weight loss? Is it a short-term fix, or something you’ll need to stay on for life? In this article, we’ll unpack what the latest research says about long-term use, how dosage evolves over time, and what Filipino users should consider before making semaglutide a part of their wellness journey.

Understanding Semaglutide: What It Does and How It Works

Semaglutide belongs to a class of medications called GLP-1 receptor agonists. Originally developed to help manage type 2 diabetes, it mimics a natural hormone in your body that regulates appetite and blood sugar. Over time, this leads to reduced hunger, improved satiety, and consistent weight loss when paired with healthy habits. Some of the most well-known brand names include Wegovy and Ozempic. While they're not always available in the Philippines under these exact names, FDA-approved versions of semaglutide are becoming increasingly accessible through licensed providers like andyou.ph.

Why It's Effective for Weight Loss

According to a study published in the New England Journal of Medicine, participants taking semaglutide lost an average of 14.9% of their body weight over 68 weeks—compared to just 2.4% in the placebo group. Additional findings from the STEP clinical trials reinforce these results, showing sustained benefits across demographics.

How Long Should You Take Semaglutide?

There’s no one-size-fits-all answer—but here’s what the science and clinical guidelines suggest:

Short-Term vs. Long-Term Use

Initial treatment phase usually lasts for 16 to 20 weeks. During this time, your dose is gradually increased to minimize side effects like nausea or constipation.
Long-term use may continue for over a year if you're responding well. Studies show sustained weight loss and improved metabolic health with extended use—up to 68 weeks and beyond.
In some cases, semaglutide may be used indefinitely, especially if weight regain occurs after stopping.

The Obesity Society and Endocrine Society both recommend long-term pharmacological intervention for obesity when lifestyle changes alone are insufficient. A recent American Journal of Managed Care article suggests that structured maintenance programs and monitoring are crucial for lasting success.

What You Need to Know About Dosage

Semaglutide dosage starts low and is increased gradually to help your body adjust. Here’s what a typical progression looks like:

Week 1–4: 0.25 mg once weekly
Week 5–8: 0.5 mg once weekly
Week 9 and beyond: 1 mg or more, depending on your provider’s recommendation

Your doctor may adjust the dose based on how your body responds and whether side effects occur. Filipino patients should work closely with board-certified specialists or licensed telehealth providers like those at andyou.ph to ensure safe adjustments.

Monitoring Your Progress

Healthcare providers typically assess progress at 3-month intervals, evaluating:

Weight changes
Appetite levels
Blood sugar and cholesterol
Medication tolerance

Regular lab tests, such as fasting glucose and liver enzymes, help ensure long-term safety.

Is It Safe to Use Semaglutide Long-Term?

What the Research Says

According to long-term studies cited by PubMed, semaglutide is generally well-tolerated over extended periods. The most common side effects include:

Nausea
Vomiting
Diarrhea
Constipation

These often decrease over time, especially with gradual dose escalation. Serious side effects like pancreatitis or gallbladder disease are rare but possible.

Who Should Avoid Long-Term Use

People with a history of medullary thyroid cancer or MEN2 syndrome
Those with severe gastrointestinal conditions

What Filipino Users Are Saying

As the popularity of semaglutide continues to rise in the Philippines, many local users have started sharing their stories on social media, forums, and through consultation feedback with healthcare providers. Common themes include consistent weight loss, more mindful eating, and improvements in energy levels.

One 42-year-old office worker in Quezon City reported losing 9 kilograms in four months and highlighted how the reduced appetite helped her avoid late-night snacking—something she had struggled with for years. Another user from Cebu noted fewer cravings for sugary drinks and more stamina during workouts. While experiences vary, many Filipino users approach semaglutide as a jumpstart to a longer-term health reset rather than a standalone solution. Several users mentioned choosing to stay on a maintenance dose for a few additional months, especially when they felt old habits creeping back in. Others consulted their doctors about cycling off after reaching their goal weight. The takeaway? Semaglutide works best when paired with lasting lifestyle changes. As these stories show, it’s less about reaching a specific number on the scale and more about regaining control and confidence over one’s health.

Alternatives and Adjuncts to Semaglutide

While semaglutide is effective, it works best when paired with:

Regular exercise: At least 150 minutes of moderate aerobic activity weekly. Institutions like the DOH encourage daily movement to reduce obesity-related conditions.
Calorie-conscious eating: Focus on whole foods, fiber, and protein.
Stress management: High stress and lack of sleep can undermine progress. Mindfulness, therapy, and even local wellness retreats may help.

What Happens If You Stop Taking Semaglutide?

Many users are concerned about regaining weight. According to JAMA, weight tends to return gradually after stopping semaglutide, especially if healthy habits aren’t maintained.

This doesn’t mean you’ll gain it all back, but it emphasizes the importance of:

Ongoing lifestyle changes
Regular check-ins with healthcare providers
Possibly restarting treatment if necessary

The Cleveland Clinic notes that metabolic markers may also worsen post-treatment, underscoring the need for a long-term plan.

Making the Most of Semaglutide in the Philippines

Semaglutide is not a magic bullet—but it can be a valuable part of a comprehensive weight loss plan. Especially in the Philippines, where access to healthy food, gym memberships, or even time for self-care can be limited, having a safe, science-backed option is empowering.

If you’re considering semaglutide, keep these in mind:

Work with a trusted provider: Telehealth platforms like andyou.ph offer licensed consultations and convenient medication access.
Know your body: Track your symptoms, energy levels, and mood over time.
Stay consistent: Weight loss takes time. Focus on long-term habits rather than short-term fixes.

Rethinking Weight Loss as a Long-Term Journey

There’s no shame in seeking medical help for weight loss. In fact, science now tells us that obesity is a chronic condition—not just about willpower, but about biology, hormones, and lifelong habits. That’s where medications like semaglutide fit in. By taking a proactive, informed approach—through sustainable routines, smart medical choices, and consistent support—you’re investing not just in your weight goals but in your long-term health. Whether you’re at the beginning of your journey or navigating maintenance, it’s worth having a plan that adapts to you. Be patient with your progress, and surround yourself with the right tools and people.

Browse our weight l o ss collection to see what options might work for you. You can also explore related posts and science-backed guides in the Andyou Health Club. Weight loss is a journey—and it’s okay if that journey includes long-term tools like semaglutide. What matters most is staying informed, safe, and supported every step of the way.

Weight Loss Team

The &you Weight Loss Team combines medical science with personal care, guiding Filipinos through their weight loss journey with trusted medications, holistic support, and culturally relevant health expertise.