Quick answer
A male fertility blood test checks testosterone, SHBG, FSH, LH, prolactin, estradiol, and TSH. FSH signals sperm making. LH signals testosterone making. A sperm test stays the main test, since it looks at sperm directly. Blood tests help explain why a sperm test came back off.
The starting point: the sperm test
The single most useful test is not a blood test. It is a semen analysis, often called a sperm test. It checks:
- Sperm count, the number per mL.
- Motility, the percent that swim well.
- Shape, the percent that look normal.
- Volume, the total amount of fluid.
World Health Organization values to know:
- Count: at least 15 million per mL.
- Total motility: at least 40%.
- Normal shape: at least 4%.
- Volume: at least 1.5 mL.
A sperm test is the first step for most couples. Blood tests come next, guided by what that test shows.
The male fertility blood panel
Total testosterone
The normal morning range is 264 to 916 ng/dL. A healthy target under 60 is 600 to 900 ng/dL. Low testosterone can lower your sex drive. It can also lower sperm making, through signals from the brain.
Free testosterone
This is worked out from total testosterone and SHBG. It is the active share your body actually uses. It is often more useful than the total number alone.
SHBG
The normal range is 10 to 80 nmol/L. Think of SHBG as a taxi for testosterone in your blood. Only the "unbooked" part, the free share, can act on your body.
FSH
The normal range is 1.5 to 12.4 IU/L. In men, FSH drives sperm making in the testicles. A high FSH hints the testicles are not doing their job well. A low FSH points to a brain-signal problem.
LH
The normal range is 1.7 to 8.6 IU/L. LH drives testosterone making in the testicles. It helps tell apart two causes of low testosterone. One is a testicle issue. The other is a brain-signal issue.
Prolactin
The normal range is under 15 ng/mL. High prolactin blocks the brain signals that drive testosterone and sperm. It is a fixable cause of male infertility.
Estradiol
The normal male range is 10 to 40 pg/mL. Men need some estradiol for normal sperm making. Very low or very high levels can hurt fertility.
TSH and Free T4
An untreated thyroid problem can lower fertility too.
DHEA-S
This comes from your adrenal glands. It is a support marker, not a stand-alone diagnosis.
Common patterns
Pattern 1: Testicle problem
Total and free testosterone are low. FSH and LH are high. Sperm counts are often low too. Causes include past injury, infection, or a genetic condition. This pattern needs a urologist and a fertility doctor.
Pattern 2: Brain-signal problem
Testosterone is low. FSH and LH are low or low-normal. Common causes are excess weight, sleep apnea, or heavy stress. This pattern is often fixable once the root cause is treated.
Pattern 3: High prolactin
Prolactin is high, often over 20 to 30. FSH, LH, and testosterone are all low. Causes include certain drugs or a small, usually harmless growth on the pituitary gland. A doctor can find the cause and treat it well.
Pattern 4: High estradiol
This often comes with excess weight. Fat tissue turns testosterone into estradiol. High estradiol can block fertility through a brain feedback loop. Weight loss often helps here.
Pattern 5: Normal hormones, sperm test off
Hormones look fine, but the sperm test does not. Common causes are heat, certain drugs, smoking, alcohol, or poor sleep. Lifestyle fixes and a recheck in 3 months often help.
Pattern 6: No clear cause found
Hormones and testicles both look normal. Sperm counts are still off, with no clear reason. Lifestyle steps, and sometimes fertility treatment, can still help here.
Lifestyle factors that affect male fertility
Heat
Hot tubs, saunas, tight clothing, and a laptop on your lap all raise heat near the testicles. This lowers sperm count and motility. It is usually fixable within 2 to 3 months.
Smoking
Smoking lowers sperm quality and can damage sperm DNA. Quitting shows results within 2 to 3 months.
Alcohol
Heavy drinking lowers testosterone and sperm quality. Light drinking has a less clear effect.
Weight
Extra weight lowers testosterone and raises estradiol. It often comes with other health issues too.
Stress and sleep
Poor sleep and high stress disrupt brain-to-testicle signals. Better sleep and stress habits help over time.
Some drugs
Anabolic steroids, opioids, some antidepressants, and some blood pressure drugs can all lower fertility. So can finasteride, a common pill for hair loss.
Diet
Enough zinc, selenium, and omega-3 support sperm quality. A diet rich in vegetables and fish is linked to better results.
Want to see how your testosterone stacks up outside a fertility context too? Our guide to testosterone testing for men covers normal versus healthy target ranges.
Testing logistics
Test testosterone in the morning, between 7 and 10 AM. This gives the most reliable reading. A sperm test is often repeated 2 to 3 weeks later, since one sample can vary. Retest hormones 4 to 6 weeks after any lifestyle change. Avoid ejaculation for 2 to 5 days before a sperm test.
See what a full &you Labs panel covers if you want your hormones checked with your other health markers.
When to see a urologist or fertility doctor
- Your sperm test comes back abnormal.
- Your testosterone is low, or your FSH is high.
- You have tried for 12 months with no pregnancy, or 6 months if your partner is over 35.
- You have a known testicle issue or past cancer treatment.
- You have serious sexual function problems.
Frequently asked questions
Can low testosterone cause infertility?
Yes, in a roundabout way. Low testosterone often comes with weak FSH and LH signals, which lowers sperm making. Testosterone therapy usually makes this worse, since it can shut down natural sperm making. Men trying to conceive should avoid it without a fertility-focused plan.
Will lifestyle changes improve sperm quality?
Often, yes, by a good amount. Quitting smoking, cutting drinks, losing weight, treating sleep apnea, avoiding heat, and easing stress can all help within 2 to 3 months.
Should men test fertility before trying to conceive?
For most couples, a sperm test makes sense after 6 to 12 months of trying. Testing earlier makes sense with known risk factors, like a past surgery or chemo.
Can supplements help male fertility?
Some evidence backs zinc, selenium, coenzyme Q10, vitamin C, vitamin E, and omega-3. The effect is often small. Lifestyle changes tend to matter more.
Are home sperm test kits accurate?
Home kits can give a rough count. They often miss motility and shape, which matter a lot. A lab-based sperm test gives a fuller, more useful picture.
Key takeaways
- Male factors cause 30 to 40% of fertility cases, so testing both partners matters.
- The sperm test is the main test. Blood tests explain the "why" behind it.
- The core panel is testosterone, SHBG, FSH, LH, prolactin, estradiol, and TSH.
- Heat, smoking, alcohol, weight, sleep, and stress are common, fixable causes.
- Testosterone therapy can block sperm making, so avoid it while trying to conceive.